37 - IMPACT OF LEVOTHYROXINE REPLACEMENT ON OXYGEN UPTAKE KINECTICS DURING EXERCISE IN SUBCLINICAL HYPOTHYROIDISM PATIENTS

Abstract

The present study aimed to analyze the effect of levothyroxine replacement (LT4) on the ventilatory response kinetics during progressive exercise on patients with subclinical hypothyroidism (SH). Twenty SH women (TSH=7,5±2,2mU/l; L-T4=1,1±0,3ng/dl) were randomized into two groups: UnTrP (untreated, n = 10) e GT (treated, n = 10). Ergoespiromety on treadmill was used, with the modified Balke protocol, in order to observe the ventilatory curves, before the treatment and six months after the TSH normalization or observation. No significant differences were observed between the groups referring to the variation amplitude of the ventilatory variables (?­­­­­­­­    O2 and ?     CO2), in T1/2      O2 and on the ratios ?      O2/?t, ?    CO2/?t and ?     E/?t. The study concludes that the LT4 replacement does not improve the ventilatory response kinetics on SH patients during progressive exercise after six months of euthyroidism. New studies are necessary due to the lack of literature on       O2 kinetics in SH.